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Since introducing the world's first EMCCD camera designed for microscopy, Photometrics has continued to develop innovative EMCCD solutions that provide unsurpassed scientific performance and reliability. Our dynamic commitment to excellence, along with stringent quality control and acclaimed customer support, has made the Cascade series the most widely used high-performance EMCCD camera line for bioscience research today!

Megapixel EMCCD Camera with True 16-Bit Dynamic Range!
The Cascade II:1024 camera utilizes a back-illuminated, frame-transfer EMCCD that is thermoelectrically cooled to -60°C without the use of any type of liquid. The combination of the sensor's small pixel size (13 x 13 microns) and large imaging format (1024 x 1024 pixels) facilitates the effective use of short exposure times with the ability to cover a greater amount of real estate on the microscope slide, thus allowing researchers to gather more data per acquisition.

The Cascade® II platform and offers >92% peak quantum efficiency, a megapixel format, and true 16-bit dynamic range.

Thanks to exclusive vacuum technology so robust it carries a lifetime guarantee, the state-of-the-art camera delivers the deepest thermoelectric air cooling available for an EMCCD-based platform. Its stainless-steel vacuum chamber (with all-metal seals) houses an e2v CCD201 - the same high-QE, back-illuminated, frame-transfer detector used in our immensely popular Cascade:512B camera.

Two independent readout amplifiers allow the Cascade II:1024 to be operated either as a high-performance EMCCD camera (with on-chip multiplication gain) for unparalleled low-light-level sensitivity or as a traditional, non-electron-multiplying CCD camera for the most precise measurement of small signal variations.


  • Intracellular trafficking studies
  • Total internal reflection fluorescence microscopy (TIRFM)
  • Single-molecule fluorescence
  • Low-light fluorescence
  • Excellent field of view, sensitivity, and resolution
  • 1024 x 1024-pixel array (13-µm pixel pitch)
  • Detector thermoelectrically cooled to -60°C
  • Vacuum guaranteed for entire lifetime of detector
  • Back-illuminated, frame-transfer EMCCD (>90% peak QE)
  • Flexible subregion readout and binning
  • Two independent readout amplifiers
  • PCI card included
  • 100% duty cycle
  • PVCAM® compatibility
  • Standard C-mount
  • 16-bit images
  • Multiple-speed operation (10, 5, or 1 MHz)
  • Individual camera calibration and certification
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