Leica EM Cryo CLEM
Explore cellular structural biology by accessing information from molecules within their native environment with the help of the EM Cryo CLEM microscope.
The EM Cryo CLEM is a dedicated cryo fluorescence microscope, designed to maintain optimal cryo conditions for smooth, contamination-free specimen handling throughout your experiment. High-resolution imaging combined with sophisticated software enables you to quickly and easily target your region of interest. You can then simply export the coordinates and image data to an electron microscope for the next steps in the correlative process.
Smooth and contamination-free specimen handling
The EM Cryo CLEM makes sure your specimen stays under optimal cryo conditions and keeps it contamination-free throughout your experiment, even during long-term image recordings.
Keep your cryo sample free of contamination
A unique cartridge system (1) allows the safe and fast handling of the specimen. The press and clip mechanism speeds up the specimen throughout and the loading time of your grids into the cryo stage.
A shuttle docking station (2) safeguards your cryo sample by keeping it always at the right temperature.
The cryo stage (3) with a synchronized aim lid prevents the specimen of air contamination by keeping it under permanent overpressure.
High resolution for precise sample targeting
Image at high resolution using the EM Cryo CLEM microscope and see the fine details of your specimen.
To enable you to find the correct target region with ease, choose the HCX PL APO 50x CLEM cryo objective. The objective is purpose-designed for high-resolution imaging of vitrified samples.
Image at high resolution using the EM Cryo CLEM microscope and see the fine details of your specimen.
To enable you to find the correct target region with ease, choose the HCX PL APO 50x CLEM cryo objective. The objective is purpose-designed for high-resolution imaging of vitrified samples.
Fast image acquisition
Record your images quickly and easily with the Cryo CLEM 3 workflow software module.
The workflow software module leads you step by step through the experiment so even a new user can quickly get the results they need.
The Cryo CLEM 3 workflow software module is implemented in the LAS X software platform for life science and offers:
- Fast acquisition of results
- Imaging of multiple target regions to create perfectly stitched mosaic images
- Reloading of complete experiment setups for fast, reproducible results
- One-click export of images and target coordinates
Easy retrieval by coordinate transfer
Target your regions using the integrated CLEM 3 software module and easily transfer the coordinates together with the image data to an electron microscope.
Safe and precise transfer of the coordinates ensures the immediate retrieval of target regions in the electron microscope.
Depending on the workflow you apply, you can either export to a Serial EM or Thermo Fisher Scientific MAPS.
Find the Cryo-Electron Tomography workflow developed in collaboration with Thermo Fisher.
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